The CGC adheres to policies established by the National Institutes of Health (NIH), the National Cancer Institute (NCI) and the National Center for Biotechnology Information (NCBI) Database of Genotypes and Phenotypes (dbGaP) for controlled data access, and data release. These policies were developed to enable broad access to genomic information while protecting the rights of the individuals who donated tissue for analysis.  

Learn more about human subjects protection and informed consent:

By using any TCGA data (inclusive of both Open and Controlled Data) on the CGC, users implicitly agree to comply with the TCGA Responsible Use and Publication Guidelines

Any user requesting access to controlled data must apply for dbGaP authorization, which is granted by an NIH Data Access Committee (DAC). DACs review and approve or disapprove all requests from the research community for data access.  Decisions to grant access are made based on whether the request conforms to the specifications within the NIH Genomic Data Sharing Policy and program specific requirements or procedures (if any). In particular, all uses proposed for controlled-access data must be consistent with the data use limitations for the dataset as indicated by the submitting institution and identified on the public website for dbGaP. DACs also review and approve or disapprove all requests for access to dbGaP data for programmatic oversight by NIH employees. All investigators, and their institutions, seeking access and use of TCGA Controlled data must acknowledge their agreement with TCGA policies and procedures which are described in the Data Use Certification associated with their application. 

Learn more about the policies associated with accessing Controlled Data: